Rapid Growth Produces Transient Cortical Weakness: A Risk Factor for Metaphyseal Fractures During Puberty
Qingju Wang, Xiao-Fang Wang, Sandra Iuliano-Burns, Ali Ghasem-Zadeh, Roger Zebaze, Ego Seeman
JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2010
Fractures of the distal radius in children have a similar incidence to that found in postmenopausal women but occur more commonly in boys than in girls. Fractures of the distal tibia are uncommon in children and show no sex specificity. About 90% of lengthening of the radius but only 30% of lengthening of the tibia during puberty occur at the distal growth plate. We speculated that more rapid modeling at the distal radial metaphysis results in a greater dissociation between growth and mineral accrual than observed at the distal tibia. We measured the macro- and microarchitecture of the distal radial and tibial metaphysis using high-resolution peripheral quantitative computed tomography in a ..View full abstract
The authors are grateful to the participants and their families. The study was made possible, in part, by a grant to Q.W, the recipient of ESCEO-Amgen fellowship awards in 2008.