Journal article

Familial Resemblance and Diversity in Bone Mass and Strength in the Population Are Established During the First Year of Postnatal Life

Qingju Wang, Markku Alen, Arja Lyytikainen, Leiting Xu, Fran A Tylavsky, Urho M Kujala, Heikki Kroger, Ego Seeman, Sulin Cheng



Familial resemblance and diversity in bone structure and strength in adulthood are determined in part during growth. Whether these characteristics are established during gestation or shortly after birth is not known. Total-body, lumbar spine, and femoral neck size and mass and indices of tibial bending strength and distal radial compressive strength were measured using bone densitometry and quantitative computed tomography in 236 girls at 18.5 years of age. Among them, 219, 141, and 105 girls had crown-heel length (CHL) and weight recorded at birth and at 6 and 12 months of age, and then height and weight were recorded at 3, 5, 10, 13, and 15 years of age in 181, 176, 127, 111, and 228 girls..

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University of Melbourne Researchers


Funding Acknowledgements

We thank the research staff-Drs Patrick HF Nicholson and Aiping Zheng, Mrs Shu Mei Cheng and Heli Vertamo, Ms Sirpa Makinen, and Mr. Erkki Helkal-for their valuable contributions. This study was supported by grants from the Academy of Finland, the Finnish Ministry of Education, the University of Jyvaskyla, and the Juho Vainion Foundation. The study was made possible, in part, by the Bridge Funding Grant Award of ASBMR 2006 to SC and by a grant to QW, the recipient of ESCEO-Amgen fellowship award, in 2008.