Journal article
Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing
VE O'Collins, MR MacLeod, SF Cox, L Van Raay, E Aleksoska, GA Donnan, DW Howells
Journal of Cerebral Blood Flow and Metabolism | Published : 2011
Abstract
There is some evidence that in animal models of acute ischaemic stroke, combinations of neuroprotective agents might be more efficacious than the same agents administered alone. Hence, we developed pragmatic, empirical criteria based on therapeutic target, cost, availability, efficacy, administration, and safety to select drugs for testing in combination in animal models of acute stroke. Magnesium sulphate, melatonin, and minocycline were chosen from a library of neuroprotective agents, and were tested in a more realistic model favoured by the STAIR (Stroke Therapy Academic Industry Roundtable). Outcome was assessed with infarct volume, neurologic score, and two newly developed scales measur..
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Awarded by Medical Research Council
Funding Acknowledgements
The authors most grateful for the wisdom and assistance of the following people who helped with animal experimentation and/or drug evaluation: Peter Batchelor, Brian Chambers, Helen Dewey, John Fernandez, Amy Jeffries, Lisa Hogan, Laura Horky, Gabrielle Liberatore, Anna Marcon, Romesh Markus, Ian Mosley, Sarah Rewell, Emily Sena, Neil Spratt, Velandai Srikanth, Bart van der Worp, JohnWilliams, Dennis Young, Jorge Zavala. The following people participated in the drug selection process: Geoffrey Donnan, Laura Horky, David Howells, Malcolm Macleod, Gabrielle Liberatore, Victoria O'Collins, Neill Spratt, Velandai Srikanth, Dennis Young, John Williams, and Jorge Zavala. Victoria O'Collins was the recipient of an APA scholarship.