Journal article

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Ying R Liu, Lisa Cardamone, R Edward Hogan, Marie-Claude Gregoire, John P Williams, Rod J Hicks, David Binns, Amelia Koe, Nigel C Jones, Damian E Myers, Terence J O'Brien, Viviane Bouilleret

JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2010

Abstract

UNLABELLED: Traumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic and structural changes in rat brains were assessed after TBI using serial (18)F-FDG PET and 3-dimensional MRI in vivo. METHODS: Rats underwent lateral fluid percussion injury (FPI; n = 16) or a sham procedure (n = 11). PET and MR images were acquired at 1 wk and at 1, 3, and 6 mo after injury. Morphologic changes were assessed using MRI-based regions of interest, and hippocampal shape changes were assessed with large-deformation high-dimensional mapping. Metabolic changes were assessed using region-of-interest analysis and statistical parametric mapping with the fle..

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Grants

Awarded by Victorian Government Transport Accident Commission (TAC)


Awarded by Australian NHMRC


Funding Acknowledgements

We thank Prof. Gary Egan and the staff of the Small Animal MRI Facility, Howard Florey Institute, for assistance with MRI scanning. We also thank the radiochemistry staff of the Peter MacCallum Cancer Centre for assistance with <SUP>18</SUP>F-FDG PET. This work was supported by the Victorian Government Transport Accident Commission (TAC) in the form of a Victorian Neurotrauma Initiative Project grant (DP0023) and a project grant from the Australian NHMRC (400088).