Role of 2-oxo and 2-thioxo modifications on the proton affinity of histidine and fragmentation reactions of protonated histidine

Grants

Funding Acknowledgements

We thank the ARC for financial support via the ARC Centre of Excellence in Free Radical Chemistry and Biotechnology. The authors gratefully acknowledge the generous allocation of computing time from both the Victorian Partnership for Advanced Computing and the NCI National Facility. The authors would also like to thank the ARC and VICS for funding of the LTQ FT hybrid mass spectrometer instrument. AKYL acknowledges the award of a Melbourne Research Scholarship from The University of Melbourne. The authors would also like to acknowledge discussions with Christopher K. Barlow and Brett Paterson, and Barbara Li for advice on the synthesis of 2-oxo-histidine.