Journal article

Targeting of whole killed bacteria to gastrointestinal M-cells induces humoral immunity in the female reproductive tract

Yok-Teng Chionh, Philip Sutton

Gut Microbes | TAYLOR & FRANCIS INC | Published : 2010

Abstract

Recently, we demonstrated that oral delivery of whole killed bacteria, when agglutinated by an M-cell targeting lectin, resulted in an enhanced systemic and mucosal antibody response, as well as a protective immunity, against the gut pathogens Helicobacter pylori and Campylobacter jejuni. Importantly, this protection was achieved without the addition of exogenous adjuvant. Here, in this addendum, we extend this initial study by reporting on the vaginal antibody response induced by these vaccinations. These data show that the targeting of M-cells within the gastrointestinal tract also induces the secretion of antigen-specific antibodies (IgG and IgA) at a distal mucosal site, namely the vagin..

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