Journal article
Does executive impairment define a frontal variant of Alzheimer's disease?
M Woodward, H Brodaty, K Boundy, D Ames, G Blanch, R Balshaw
International Psychogeriatrics | Published : 2010
Abstract
Background: People with Alzheimer's disease (AD) who present with prominent frontal features such as a dysexecutive syndrome may be difficult to differentiate clinically from subjects with frontotemporal lobar degeneration (FTLD). This study was performed to improve the differential diagnosis between AD and FTLD and to better characterize the AD subgroup with greater executive dysfunction. Methods: Using a well-defined prospectively studied cohort of cognitively impaired subjects, which included those with AD and with FTLD, we nominated a frontal variant of AD (FvAD) group as those AD subjects with the lowest quartile of scores on the Frontal Assessment Battery (FAB), indicating greatest exe..
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Funding Acknowledgements
The first four authors have all been members of advisory boards funded by the companies marketing galantamine, donepezil and rivastigmine. They have been members of the PRIME database Scientific Advisory Committee (SAC), funded by Janssen-Cilag Pty Ltd Australia, and were funded for this activity. Greg Blanch is an employee of Janssen-Cilag Pty Ltd Australia and Robert Balshaw is an employee of Syreon Corporation, Canada, which processed the data and was paid by Janssen-Cilag Pty Ltd Australia to do this.