Journal article
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
CC Rowe, KA Ellis, M Rimajova, P Bourgeat, KE Pike, G Jones, J Fripp, H Tochon-Danguy, L Morandeau, G O'Keefe, R Price, P Raniga, P Robins, O Acosta, N Lenzo, C Szoeke, O Salvado, R Head, R Martins, CL Masters Show all
Neurobiology of Aging | Published : 2010
Abstract
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed 11C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-ε4 carriers vs 21% in noncarriers) and increased with age, most strongly in ε4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in ε4 carriers. There was no correlation with cognition in HC or MCI. PiB bin..
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Funding Acknowledgements
The study was supported by the Commonwealth Scientific Industrial Research Organization (CSIRO) P-Health Flagship Collaboration Fund through the Australian Imaging, Biomarkers and Lifestyle Flagship study of Ageing (Australian Imaging, Biomarkers and Lifestyle [AIBL]), the Austin Hospital Medical Research Foundation, Neurosciences, Victoria, and the University of Melbourne.