Journal article

Reduced cerebellar diameter in very preterm infants with abnormal general movements

Alicia J Spittle, Lex W Doyle, Peter J Anderson, Terrie E Inder, Katherine J Lee, Roslyn N Boyd, Jeanie LY Cheong

Early Human Development | ELSEVIER IRELAND LTD | Published : 2010


BACKGROUND: Abnormal General Movements (GMs) early in life are predictive of later neuromotor deficits and are related to white matter abnormalities on magnetic resonance imaging (MRI). However, other structural correlates of abnormal GMs have not been defined. AIMS: The objective of this study was to explore brain-metrics (linear brain measurements on MRI representative of 3-D brain volumes) at term as a predictor of abnormal GMs at 1 and 3months' corrected age in preterm infants. It was hypothesized that abnormal GMs would be related to reduced brain-metrics in primary motor areas, namely the cerebellum and parietal lobes. STUDY DESIGN: Eighty three preterm infants (<30weeks' gestational a..

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Awarded by National Health Medical Council (Australia)

Funding Acknowledgements

We would like to thank Jane Orton, Nisha Brown and the VIBeS Plus team, Murdoch Children's Research Institute for their assistance in collecting data. We acknowledge support from the National Health Medical Council (Australia) Public Health Postgraduate Scholarship for AS (Grant ID: 334390), NHMRC Career Development Award for RB and NHMRC Project grant (ID 284512), Murdoch Children's Research Institute, Myer Foundation, Allens Arthur Robinson, Cerebral Palsy Institute, Australia, and Thyne Reid Foundation.