No Associations Between Telomere Length and Age-Sensitive Indicators of Physical Function in Mid and Later Life
Karen Anne Mather, Anthony Francis Jorm, Peter John Milburn, Xiaoyun Tan, Simon Easteal, Helen Christensen
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | OXFORD UNIV PRESS INC | Published : 2010
Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with age-related loss of physical function, independent of age. In this cross-sectional Australian population study, the associations between peripheral blood leukocyte telomere length and age-sensitive indicators of physical function (lung function, blood pressure, and grip strength) were examined in two narrow age range cohorts aged 44-49 years (n = 351) and 64-70 years (n = 295). Telomere length was correlated with systolic blood pressure but only for women of the younger cohort and in the opposite direction to th..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This study was supported by an Australian National Health and Medical Research Council (NHMRC) Program Grant 179805 and an R.M. Gibson Grant from the Australian Association of Gerontology. A.F.J. and H.C. are funded by NHMRC Fellowships.