Journal article

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

E Theodoratou, H Campbell, A Tenesa, R Houlston, E Webb, S Lubbe, P Broderick, S Gallinger, EM Croitoru, MA Jenkins, AK Win, SP Cleary, T Koessler, PD Pharoah, S Kuery, S Bezieau, B Buecher, NA Ellis, P Peterlongo, K Offit Show all



Awarded by Cancer Research UK

Awarded by Scottish Government Chief Scientist Office

Awarded by Medical Research Council

Awarded by Ministerio de Educacion y Ciencia

Awarded by Spanish Networks RTICCC

Awarded by Instituto de Salud Carlos III

Awarded by Chief Scientist Office

Awarded by The Francis Crick Institute


Funding Acknowledgements

We thank all the study participants and the many colleagues world wide who contributed to recruitment. We are particularly grateful to Ruth Wilson, Rosa Bisset, Nicola Cartwright and Gisela Johnstone, and all those who contributed to recruitment, data collection and data curation for the Scottish COGS and SOCCS studies. This work was supported by grants from Cancer Research UK (C348/A3758, C348/A8896), Scottish Government Chief Scientist Office (K/OPR/2/2/D333, CZB/4/94, CZB/4/449); Medical Research Council (G0000657-53203); Centre Grant from CORE as part of the Digestive Cancer Campaign ( ET is funded by a Cancer Research UK Fellowship C31250/A10107. The work at the Institute of Cancer Research is supported grants from Cancer Research UK (supported by Bobby Moore), Steven Lubbe is supported by a Cancer Research UK PhD Studentship. The work in Canada was made possible through collaboration and cooperative agreements with the Colon Cancer Family Registry and PIs. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating institutions or investigators in the Colon CFR, nor does mention of trade names, commercial products, or organisations imply endorsement by the US Government or the Colon CFR. The work in Cambridge (SEARCH) is funded through a programme grant from Cancer Research UK, TK is funded by the Foundation Dr Henri Dubois-Ferriere Dinu Lipatti. The work in France was supported by a regional Hospital Clinical Research Program, the Regional Council of Pays de la Loire, the Groupement des Entreprises Francaises dans la LUtte contre le Cancer, the Association Anne de Bretagne Genetique and the Ligue Regionale Contre le Cancer. The work in Stockholm was supported by The Swedish Cancer Society, The Swedish Research Council and The Stockholm Cancer Foundation. The work in Spain was supported by the Ministerio de Educacion y Ciencia (SAF09-7319), Spanish Networks RTICCC (RD06/0020/1050, 1051), Instituto de Salud Carlos III grants (FIS PI03/0114 and FIS 05/1006 and CIBERESP).