Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions
Nathan J Godde, Ryan C Galea, Imogen A Elsum, Patrick O Humbert
Journal of Mammary Gland Biology and Neoplasia | SPRINGER/PLENUM PUBLISHERS | Published : 2010
Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects of mammary development and has been proposed to be a key process in breast cancer progression. Such epithelial-mesenchymal plasticity requires complex cellular reprogramming to orchestrate a change in cell shape to an alternate morphology more conducive to migration. During this process, epithelial characteristics, including apical-basal polarity and specialised cell-cell juncti..View full abstract
The authors would like to acknowledge Helen Pearson, Andreas Moeller and Robin Anderson for helpful discussions and comments during the writing of this manuscript. POH was supported by a Career Development Award from the Australian NHMRC, RG by an Australian Postgraduate Award and IE by a Postgraduate Cancer Research Scholarship from the Cancer Council Victoria. This work was supported by grants from the Australian NHMRC, Association for International Cancer Research UK and Cancer Council Victoria.