Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Grants

Funding Acknowledgements

We thank Dr. Henry C. Marsh (Celldex Therapeutics, Needham, MA) for providing sCR1, CR1 monoclonal antibodies 4D6 and 6B1, and comments on the manuscript. We thank Ronald Taylor (University of Virginia School of Medicine, Charlottesville, VA) and Thalachallour Mohanakumar (University of Virginia School of Medicine, Charlottesville, VA) for CR1 monoclonal antibodies 1B4, 3D9, 7G9, 9H3, and KuN241; the Australian Red Cross (Dr. Jenny Condon) for the blood samples; The Walter and Eliza Hall Institute's Monoclonal Facility (The Walter and Eliza Hall Institute of Medical Research, Melbourne) for antibody production; and Stuart Wyithe (Department of Physics, University of Melbourne, Melbourne) for statistical analysis. Infrastructure was supported by Victoria State Government Offer Information Statement and National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme grants. A.F.C. is a Howard Hughes International Scholar and an Australia Fellow of the National Health and Medical Research Council. J.G.B. is supported by a National Health and Medical Research Council Career Development award. This work was supported by the National Health and Medical Research Council, the Darwin Trust of Edinburgh (studentship to P.B.T-Q.), and the Wellcome Trust.