Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
Ingela Vikstrom, Sebastian Carotta, Katja Luethje, Victor Peperzak, Philipp J Jost, Stefan Glaser, Meinrad Busslinger, Philippe Bouillet, Andreas Strasser, Stephen L Nutt, David M Tarlinton
Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2010
Awarded by National Health and Medical Research Council (NHMRC) Australia
Awarded by Leukemia and Lymphoma Society
Awarded by NIH
This work was supported in part by grants from the National Health and Medical Research Council (NHMRC) Australia (356202 to D. M. T. and S.L.N. and 461221 to P. B. and A. S.), the Leukemia and Lymphoma Society (SCOR grant 7413), and the NIH (CA43540 and CA80188). D. M. T. and A. S. are supported by fellowships from the NHMRC; S.L.N. by a Pfizer Australia Research Fellowship; I. V. by the Olle Engkvist Byggmastare and Wenner-Gren Foundations; K. L. by a fellowship from the German Academic Exchange Service; P. B. by the Charles and Sylvia Viertel Charitable Foundation; and M. B. by Boehringer Ingelheim. DNA sequence data are available in GenBank (accession number HM804028-HM804084). We are indebted to the facilities of our respective institutes, particularly those responsible for animal husbandry and flow cytometry. We also acknowledge the assistance of L. O'Reilly for Western blot antibodies and the many helpful discussions with members of the Walter and Eliza Hall Institute B Cell Program. Author contributions are as follows: I. V. and D. M. T. designed the research; I. V., K. L., S. G., V. P., S. C., and P.J. performed experiments and contributed to interpretation and discussion; M. B., P. B., A. S., and S.L.N. contributed to the design of experiments, interpretation of results, and drafting the manuscript; I. V., K. L., and V. P. analyzed data and prepared figures; and I. V. and D. M. T. wrote the manuscript.