Risk factors for invasive breast cancer when core needle biopsy shows ductal carcinoma in situ

Abstract

Hypothesis: A core needle biopsy (CNB) diagnosis of ductal carcinoma in situ (DCIS) may be associated with a final diagnosis of invasive cancer. Preoperative radiologic, clinical, and pathological features may identify patients at high risk of diagnostic upstaging, who may be appropriate candidates for sentinel node biopsy at initial surgery. Design: Review of prospectively collected database. Setting: Tertiary teaching referral hospital and a population-based breast screening center. Patients: Consecutive patients from January 1, 1994, to December 31, 2006, whose CNB findings showed DCIS or DCIS with microinvasion. Main Outcome Measures: Upstaging to invasive cancer. Results: Eleven of 15 c..