Journal article

Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice

Olivia Dean, Ashley I Bush, Michael Berk, David L Copolov, Maarten van den Buuse

Pharmacology, Biochemistry and Behavior | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2010

Abstract

Oxidative stress has been implicated in several psychiatric illnesses, including schizophrenia. Glutathione is the brain's primary antioxidant and decreased levels of brain glutathione are reported in schizophrenia. Prepulse inhibition (PPI) is a measure of sensory gating, and PPI is reduced in schizophrenia. This study aimed to investigate the effects of brain glutathione depletion on PPI regulation. Rats and mice were treated with the glutathione-depleting agent, 2-cyclohexene-1-one (CHX), and tested for baseline PPI and its disruption by treatment with amphetamine and MK-801. Treatment with CHX caused significant depletion of GSH in frontal cortex and striatum of rats and mice. Baseline P..

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