Journal article
Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria
L Reiling, JS Richards, FJI Fowkes, AE Barry, T Triglia, W Chokejindachai, P Michon, L Tavul, PM Siba, AF Cowman, I Mueller, JG Beeson
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2010
Abstract
Abs targeting blood-stage Ags of Plasmodium falciparum are important in acquired immunity to malaria, but major targets remain unclear. The P. falciparum reticulocyte-binding homologs (PfRh) are key ligands used by merozoites during invasion of erythrocytes. PfRh2a and PfRh2b are functionally important members of this family and may be targets of protective immunity, but their potential role in human immunity has not been examined. We expressed eight recombinant proteins covering the entire PfRh2 common region, as well as PfRh2a-and PfRh2b-specific regions. Abs were measured among a cohort of 206 Papua New Guinean children who were followed prospectively for 6 mo for reinfection and malaria...
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (Project Grant and Career Development Award to J.B., Postgraduate Research Scholarship to J.R., Training Award to F.F., Project Grant to A.B., Program Grant to A.C., Infrastructure for Research Institutes Support Scheme Grant 361646); the Miller Fellowship of the Walter and Eliza Hall Institute (to J.B.); an Australian Research Council Future Fellowship (to J.B.); an Innovation Fellowship from the Victorian Endowment for Science Knowledge and Innovation (to A.B.); the Australia-India Strategic Research Fund of the Australian Government; a Victorian State Government Operational Infrastructure Support grant; and the International Nutrition Foundation/Ellison Medical Foundation Fellowship (to W.C.).