Journal article
Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease
EM Vazey, M Dottori, P Jamshidi, D Tomas, MF Pera, M Horne, B Connor
Cell Transplantation | SAGE PUBLICATIONS INC | Published : 2010
Abstract
Human neural precursors (hNP) derived from embryonic stem cells (hESC) may provide a viable cellular source for transplantation therapy for Huntington's disease (HD). However, developing effective transplantation therapy for the central nervous system (CNS) using hESC relies on optimizing the in vitro production of hNP to control appropriate in vivo posttransplantation neuronal differentiation. The current study provides the first direct in vivo comparison of the transplant efficiency and posttransplantation characteristics of spontaneously derived and noggin-primed hNP following transplantation into the quinolinic acid (QA) rat model of HD. We show that spontaneously derived and noggin-prim..
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Funding Acknowledgements
This work was supported by the Health Research Council of New Zealand, the Royal Society of New Zealand, and the University of Auckland Staff Research Fund. E.M.V. was supported a Neurological Foundation of New Zealand W and B Miller Postgraduate Scholarship.