Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance
Douglas E Crompton, Ingrid E Scheffer, Isabella Taylor, Mark J Cook, Penelope A McKelvie, Danya F Vears, Kate M Lawrence, Jacinta M McMahon, Bronwyn E Grinton, Anne M McIntosh, Samuel F Berkovic
BRAIN | OXFORD UNIV PRESS | Published : 2010
Temporal lobe epilepsy is the commonest partial epilepsy of adulthood. Although generally perceived as an acquired disorder, several forms of familial temporal lobe epilepsy, with mesial or lateral seizure semiology, have been described. Descriptions of familial mesial temporal lobe epilepsy have varied widely from a benign epilepsy syndrome with prominent déjà vu and without antecedent febrile seizures or magnetic resonance imaging abnormalities, to heterogeneous, but generally more refractory epilepsies, often with a history of febrile seizures and with frequent hippocampal atrophy and high T₂ signal on magnetic resonance imaging. Compelling evidence of a genetic aetiology (rather than cha..View full abstract
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Awarded by National Health and Medical Research Council of Australia
UCB Pharma (an educational fellowship award to D.E.C.); National Health and Medical Research Council of Australia (Program Grant ID 400121 to S.F.B and I.E.S.).