Journal article

Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?

Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson, Anita Wluka



INTRODUCTION: Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structure in young and healthy adults has not been examined. The aim of this study was to examine the relationship between body mass index (BMI), and change in BMI over the preceding 10-year period, and knee structure (cartilage defects, cartilage volume and bone marrow lesions (BMLs)) in a population-based sample of young to middle-aged females. METHODS: One hundred and forty-two healthy, asymptomatic females (range 30 to 49 years) in the Barwon region of Australia, underwent magnetic resonance imaging (MRI) during 2006 to 2008. BMI measured 10 years prior (1994 to 1997..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Awarded by NHMRC Public Health Australia

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (251638, 436665), the Victorian Health Promotion Foundation, LEW Carty Foundation and Arthritis Australia. SL Brennan was supported by NHMRC PhD Scholarship (519404). Y Wang is the recipient of a NHMRC Public Health Australia Training Fellowship (465142). AE Wluka is the recipient of NHMRC Clinical Career Development Award (545876). These funding bodies had no role in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We thank the participants who made this study possible, and the MRI technicians at Barwon Medical Imaging, Barwon Health for their support in imaging the participants.