Journal article
Interaction of crohn's disease susceptibility genes in an australian paediatric cohort
J Wagner, WH Sim, JA Ellis, EK Ong, AG Catto-Smith, DJS Cameron, RF Bishop, CD Kirkwood
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Genetic susceptibility is an important contributor to the pathogenesis of Crohn's disease (CD). We investigated multiple CD susceptibility genes in an Australian paediatric onset CD cohort. Newly diagnosed paediatric onset CD patients (n = 72) and controls (n = 98) were genotyped for 34 single nucleotide polymorphisms (SNPs) in 18 genetic loci. Gene-gene interaction analysis, gene-disease phenotype analysis and genetic risk profiling were performed for all SNPs and all genes. Of the 34 SNPs analysed, four polymorphisms on three genes (NOD2, IL23R, and region 3p21) were significantly associated with CD status (p<0.05). All three CD specific paediatric polymorphisms on PSMG1 and TNFRSF6B showe..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The project was supported by research grants from the Jack Brockhoff Foundation, Australia, the Murdoch Children Research Institute, Australia, and from the Broad Medical Research Program, The Eli and Edythe Broad Foundation, USA. C. Kirkwood is supported by a Career Development Awards fellowship from the National Health and Medical Research Council, Australia (607347). J Ellis is supported by a National Health and Medical Research Council Capacity Building Grant in Population Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation to the manuscript.