Journal article

Molecular epidemiology of Saccharomyces cerevisiae in an immunocompromised host unit

Karl V Clemons, Juha H Salonen, Jouni Issakainen, Jukka Nikoskelainen, Michael J McCullough, Jacks J Jorge, David A Stevens

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | ELSEVIER SCIENCE INC | Published : 2010

Abstract

Saccharomyces cerevisiae is increasingly recognized clinically, and repeated isolations from patients on a hematology unit in Turku, Finland, led to an epidemiologic investigation. Isolates were recovered from multiple body sites of 23 patients (n = 180) from 1994 to 1995 and from 29 patients (n = 45) from 1997 to 2002; these plus 2 from the hospital kitchen were identified as S. cerevisiae. Isolates were genotyped by restriction fragment length polymorphism (RFLP) of genomic DNA after EcoR1 digestion. Of 108 isolates, 97 (95 patient isolates and 2 from the hospital kitchen) were DNA group B and identical in RFLP pattern. The remaining 11 isolates were DNA group A; 2 patients that shared a r..

View full abstract

University of Melbourne Researchers