Novel interactions between UFH and TFPI in children
Fiona Newall, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick, Paul Monagle, Vera Ignjatovic
BRITISH JOURNAL OF HAEMATOLOGY | WILEY | Published : 2010
The impact of age upon therapeutic response to unfractionated heparin (UFH) in children is proposed to reflect quantitative and potentially qualitative differences in coagulation proteins across childhood. This study explores the UFH-dependent tissue factor pathway inhibitor (TFPI) release in children compared to previously published data in adults. Children <16 years of age undergoing cardiac angiography formed the population for this prospective cohort study. TFPI release was measured prior to (baseline) and at 15, 30, 45 and 120 min post-UFH dose. This study demonstrated that, whilst the immediate release of TFPI post-UFH was similar in children compared to adults, TFPI release in childre..View full abstract
Related Projects (1)
Awarded by NHMRC
This project was supported by an NHMRC Research Grant #454385. Dr. Ignjatovic was supported by the Sanofi-Aventis Clinical Research Fellowship. Dr. Newall held an Australian Postgraduate Award.