Tribulations of a prostate cancer trial - Lessons learned from TOAD, a Cancer Council Victoria and Transtasman Radiation Oncology Group trial
Gillian M Duchesne, Henry H Woo, Deborah Howell, Mary Kaimakamis, Evan Kemp
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY | WILEY | Published : 2010
From 2004–2009 a total of 226 out of a target of 750 prostate cancer patients have been randomised into the Timing of Androgen Deprivation trial between immediate and delayed androgen deprivation. A screening log was kept by participating centres for the first 928 patients, which documented the reasons for non-entry into the trial; 42.7% of screened patients were ineligible and a further 33.0% were not entered for other reasons. Fewer than 10% of patients cited not wanting to be part of a clinical trial as a reason for non-entry. Strategies to improve recruitment included broadening the eligibility criteria, encouraging international collaboration, the use and support of research nurses in t..View full abstract
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Awarded by National Health & Medical Research Council
This study has received financial support from the National Health & Medical Research Council (grant number 350201), The Cancer Councils of Victoria, New South Wales, Queensland and South Australia, the Royal Australian and New Zealand College of Radiologists, and Hospira and Astra Zeneca. We would like to acknowledge the contributions of the recruiting centres listed below, and of the members of the original trial management committee, particularly Mr Rodney Syme, who led Part B of the study for newly diagnosed incurable patients. We also thank the investigators at the following sites who have supported the study. Sir Charles Gairdner Hospital (WA), Westmead Hospital (NSW), Woo, Dr Henry (NSW), Mater QRI (QLD), Repatriation General Hospital (SA), Peter MacCallum Cancer Centre (VIC), Nepean Cancer Care Centre (NSW), Geelong Hospital (VIC), Liverpool Hospital (NSW), Christchurch Hospital (NZ), Dunedin Hospital (NZ), Illawarra Cancer Centre (NSW), Newcastle Mater (NSW), Royal Prince Alfred (NSW), Auckland Hospital (NZ), Princess Alexandra Hospital (QLD), Waikato Hospital (NZ), East Coast Cancer Centre (Premion) (QLD), Royal Brisbane Hospital (QLD), St George Hospital (NSW), Alfred Hospital (VIC), Campbelltown Hospital (NSW), Sinclair, Mr Graham (SA Urol), Concord Repatriation Hosp (NSW), Fremantle Hospital (WA), Royal North Shore Hospital (NSW), and Vivian, Justin (WA).