Journal article

Timing of Immune Escape Linked to Success or Failure of Vaccination

Jeanette C Reece, Liyen Loh, Sheilajen Alcantara, Caroline S Fernandez, John Stambas, Amy Sexton, Robert De Rose, Janka Petravic, Miles P Davenport, Stephen J Kent

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2010

Abstract

Successful vaccination against HIV should limit viral replication sufficiently to prevent the emergence of viral immune escape mutations. Broadly directed immunity is likely to be required to limit opportunities for immune escape variants to flourish. We studied the emergence of an SIV Gag cytotoxic T cell immune escape variant in pigtail macaques expressing the Mane-A*10 MHC I allele using a quantitative RT-PCR to measure viral loads of escape and wild type variants. Animals receiving whole Gag expressing vaccines completely controlled an SIV(mac251) challenge, had broader CTL responses and exhibited minimal CTL escape. In contrast, animals vaccinated with only a single CTL epitope and chal..

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