Timing of Immune Escape Linked to Success or Failure of Vaccination
Jeanette C Reece, Liyen Loh, Sheilajen Alcantara, Caroline S Fernandez, John Stambas, Amy Sexton, Robert De Rose, Janka Petravic, Miles P Davenport, Stephen J Kent
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2010
Successful vaccination against HIV should limit viral replication sufficiently to prevent the emergence of viral immune escape mutations. Broadly directed immunity is likely to be required to limit opportunities for immune escape variants to flourish. We studied the emergence of an SIV Gag cytotoxic T cell immune escape variant in pigtail macaques expressing the Mane-A*10 MHC I allele using a quantitative RT-PCR to measure viral loads of escape and wild type variants. Animals receiving whole Gag expressing vaccines completely controlled an SIV(mac251) challenge, had broader CTL responses and exhibited minimal CTL escape. In contrast, animals vaccinated with only a single CTL epitope and chal..View full abstract
Awarded by NHMRC
Supported by NHMRC awards 508902 and 454553 (http://www.nhmrc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.