High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
Kathryn E Holt, Stephen Baker, Sabina Dongol, Buddha Basnyat, Neelam Adhikari, Stephen Thorson, Anoop S Pulickal, Yajun Song, Julian Parkhill, Jeremy J Farrar, David R Murdoch, Dominic F Kelly, Andrew J Pollard, Gordon Dougan
BMC Infectious Diseases | BMC | Published : 2010
Awarded by NHMRC of Australia
This work was funded by The Wellcome Trust. We thank Mark Achtman for access to GyrA SNP typing in his laboratory. S. Typhi isolates analyzed in this study were collected during the course of a larger study of pediatric bacterial disease at Patan Hospital, and we would like to acknowledge the contribution of the parents and children in participating in the study; the medical and nursing staff in the emergency department and paediatric wards who helped to identify participants and collect clinical specimens; Ram Babu Shrestha and the staff of the laboratory of Patan hospital; Dr Mark Zimmerman who facilitated the organisation of the study; Amy Slender of the Oxford Vaccine Group; the staff of PneumoADIP including Orin Levine, Maria Knoll, Farzana Muhib; the clinical research fellows Rahul Pradhan, Sarah Hanieh, Julie Lewis; research fellows Mainga Hamaluba, Eleri Williams, Mitu Maskey and Sandeep Mahat; microbiology staff at the Christian Medical College Vellore; funding was provided by PneumoADIP, the University of Oxford Department of Paediatrics, University of Otago Department of Pathology and an unrestricted grant from Chiron Vaccines. AJP is a Jenner Institue Investigator. KEH was supported by a PhD studentship from the Wellcome Trust and a Fellowship from the NHMRC of Australia #628930. SB is supported by the OAK foundation through the University of Oxford.