Journal article

A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25

Pirro G Hysi, Terri L Young, David A Mackey, Toby Andrew, Alberto Fernandez-Medarde, Abbas M Solouki, Alex W Hewitt, Stuart Macgregor, Johannes R Vingerling, Yi-Ju Li, M Kamran Ikram, Lee Yiu Fai, Pak C Sham, Lara Manyes, Angel Porteros, Margarida C Lopes, Francis Carbonaro, Samantha J Fahy, Nicholas G Martin, Cornelia M van Duijn Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2010


Awarded by European Community

Awarded by European Network of Genetic and Genomic Epidemiology (ENGAGE)

Awarded by FP-5 GenomEUtwin Project

Awarded by US National Institutes of Health (NIH)/National Eye Institute (NEI)

Awarded by Junta de Castilla y Leon (JcyL)

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Genetic Cluster Computer

Awarded by Instituto de Salud Carlos III (ISCIII)

Awarded by Medical Research Council

Funding Acknowledgements

The King's College London authors acknowledge funding from the Wellcome Trust, the European Union MyEuropia Marie Curie Research Training Network, Guide Dogs for the Blind Association, the European Community's FP7 (HEALTH-F2- 2008-201865-GEFOS), European Network of Genetic and Genomic Epidemiology (ENGAGE) (HEALTH-F4-2007-201413), the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254), US National Institutes of Health (NIH)/National Eye Institute (NEI) grant 1RO1EY018246 and genotyping by the NIH Center for Inherited Disease Research. The study also received support from the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service Foundation Trust partnering with King's College London. We are grateful to the volunteer twins, C. Smoliner and M. Liew, and to R. Metlapally and Felicia Hawthorne in T.L.Y.'s laboratory for RASGRF1 expression studies.The Rotterdam Study acknowledges Netherlands Organisation of Scientific Research (NWO); the Erasmus Medical Center; Netherlands Organization for the Health Research and Development (ZonMw); UitZicht; Research Institute for Diseases in the Elderly (RIDE); the European Commission Directorate-General XII; the Municipality of Rotterdam; Netherlands Genomics Initiative (NGI); Lijf en Leven; MD Fonds; Henkes; Oogfonds; Stichting Wetenschappelijk Onderzoek Het Oogziekenhuis (SWOO); Swart van Essen; Bevordering van Volkskracht; Blindenhulp; Landelijke Stichting voor Blinden en Slechtzienden (LSBS); Rotterdamse Vereniging voor Blindenbelangen; OOG Foundation; Algemene Nederlandse Vereniging ter Voorkoming van Blindheid (ANVVB); Rotterdam Eye Institute (REI); Lameris Ootech BV; Topcon BV; Heidelberg Engineering; A. Hooghart, C. Brussee, R. Bernaerts-Biskop, P. van Hilten, P. Arp, M. Jhamai, M. Moorhouse, J. Vergeer, M. Verkerk, S. Bervoets and P. van der Spek. E. S., A. F.-M. and L. M. were supported by grants from Instituto de Salud Carlos III (ISCIII) (FIS PS09/01979) and Junta de Castilla y Leon (JcyL) (SA044A08 and GR93) and received institutional support from Red Tematica de Investigacion Cooperativa en Cancer (RTICC) (RD06/0020/000), ISCIII, Spain.The Australian group acknowledges the National Health and Medical Research Council (NHMRC) for the Australian Twin Registry (ATR) Enabling Grant, Project Grant 350415, Medical Genomics Grant, and the Genetic Cluster Computer (NWO 480-05-003), Clifford Craig Medical Research Trust, Ophthalmic Research Institute of Australia (ORIA), American Health Assistance Foundation (AHAF), Peggy and Leslie Cranbourne Foundation, Foundation for Children and Jack Brockhoff Foundation.The 1958 British Birth Cohort was funded for biomedical assessment (Medical Research Council), for the GWAS (Wellcome Trust 083478) and analysis at Great Ormond Street Hospital/University College London (UCL). Institute of Child Health and Moorfields Eye Hospital/Institute of Ophthalmology, UCL were each part-funded by NIHR Biomedical Research Centres awards.