Journal article

Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

Gudmar Thorleifsson, G Bragi Walters, Alex W Hewitt, Gisli Masson, Agnar Helgason, Andrew DeWan, Asgeir Sigurdsson, Adalbjorg Jonasdottir, Sigurjon A Gudjonsson, Kristinn P Magnusson, Hreinn Stefansson, Dennis SC Lam, Pancy OS Tam, Gudrun J Gudmundsdottir, Laura Southgate, Kathryn P Burdon, Maria Soffia Gottfredsdottir, Micheala A Aldred, Paul Mitchell, David St Clair Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2010


Awarded by Wellcome Trust

Awarded by US National Institutes of Health (NIH)/National Eye Institute

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

We thank all the participants whose contribution made this study possible, as well as their ophthalmologists. We also thank the personnel at deCODE recruitment center and core facilities for their hard work and enthusiasm. We would also like to acknowledge A. Hill (University Hospitals of Leicester National Health Service (NHS) Trust) for invaluable help with sample collection and the Wellcome Trust for funding (programme grant 062346/Z/00/Z and project grant 078751/Z/05/Z). The authors acknowledge financial support from the UK Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's and St. Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust. We also thank the following organizations for their financial support: Clifford Craig Medical Research Trust; Ophthalmic Research Institute of Australia; Pfizer Australia; Glaucoma Australia; American Health Assistance Foundation; the glaucoma research foundation and the Australian National Health and Medical Research Council (NHMRC); the International Glaucoma Association, UK and the Eire Glaucoma Society and Optegra UK Ltd. J. E. C. is supported in part by an NHMRC Practitioner Fellowship, and D. A. M. is a Pfizer Australia Research Fellow. We would also like to thank O. Wallerman, M. Jansson, L.-I. Larsson and L. Tomic for their assistance and the Swedish Research Council for financial support. The authors acknowledge the funding and support of the following organizations: the US National Institutes of Health (NIH)/National Eye Institute grant 1RO1EY018246 and the NIH Center for Inherited Diseases Research (CIDR) (PI: T. Young); the Verto Institute, the American Health Assistance Foundation (AHAF) National Glaucoma Research and the Ellison Foundation for Aging Research; and the Southampton Wellcome Trust Clinical Research Facility. We thank D. R. Nyholt, G. Montgomery, S. Medland, S. Gordon, A. Henders, B. McEvoy, M. J. Wright, M. J. Campbell and A. Caracella for obtaining funding for and processing the Australian genotype data. S. M. is supported by an Australian NHMRC Career Development Award.