Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

William S Stevenson; Craig D Hyland; Jian-Guo Zhang; Phillip O Morgan; Tracy A Willson; Anthony Gill; Adrienne A Hilton; Elizabeth M Viney; Melanie Bahlo; Seth L Masters; Sarah Hennebry; Samantha J Richardson; Nicos A Nicola; Donald Metcalf; Douglas J Hilton; Andrew W Roberts; Warren S Alexander

Journal article

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

William S Stevenson, Craig D Hyland, Jian-Guo Zhang, Phillip O Morgan, Tracy A Willson, Anthony Gill, Adrienne A Hilton, Elizabeth M Viney, Melanie Bahlo, Seth L Masters, Sarah Hennebry, Samantha J Richardson, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts, Warren S Alexander

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2010

DOI: 10.1073/pnas.1010390107

University of Melbourne Researchers

Melanie Bahlo Author Mathematics and Statistics

Douglas Hilton Author Medical Biology (W.E.H.I.)

Nicos Nicola Author Medical Biology (W.E.H.I.)

Andrew Roberts Author

Warren Alexander Author Medical Biology (W.E.H.I.)

Grants

Awarded by Australian National Health and Medical Research Council of Australia

Funding Acknowledgements

We thank Jason Corbin and Janelle Lochland for technical assistance and David De Sousa and Malcolm McConville for helpful discussions and input. This work was supported by Program Grant 461219, fellowships (to D.J.H.,W.S.A., N.A.N., A.W.R., and M.B.), a scholarship (to W.S.S.), and Independent Research Institutes Support Scheme Grant 361646 from the Australian National Health and Medical Research Council of Australia; a Fellowship from the Cancer Council, Victoria (to D.M.); the Australian Cancer Research Fund; a Victorian State Government Operational Infrastructure Support grant; and MuriGen Pty. Ltd.