Journal article
Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
JS Richards, DI Stanisic, FJI Fowkes, L Tavul, E Dabod, JK Thompson, S Kumar, CE Chitnis, DL Narum, P Michon, PM Siba, AF Cowman, I Mueller, JG Beeson
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2010
DOI: 10.1086/656413
Abstract
Background. Antibodies targeting blood stage antigens are important in protection against malaria, but the principle targets remain unclear. Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance. Methods. We examined antibodies among 206 Papua New Guinean children who were treated with antimalarials at enrolment and observed prospectively for 6 months for reinfection and malaria. Immunoglobulin (Ig) G, IgG subclasses, and IgM to different regions of EBA175, EBA140, and EBA181 expressed as recombinant proteins were assessed in comparison with s..
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Awarded by Australian Government
Funding Acknowledgements
The National Health and Medical Research Council of Australia (project grant and career development award to J.G.B., postgraduate research fellowship to J.S.R., and training award to F.J.F. [IRIISS grant 361646]), the Australia-India Strategic Research Fund (Department of Innovation, Industry, Science, and Research, Australian Government), Australian Research Council (Future Fellowship to J.G.B.), and the Victorian State Government Operational Infrastructure Support grant.