Journal article
The core network in absence epilepsy: Differences in cortical and thalamic BOLD response
PW Carney, RAJ Masterton, AS Harvey, IE Scheffer, SF Berkovic, GD Jackson
Neurology | Published : 2010
Abstract
Objectives: We used EEG-fMRI to study epileptiform activity in a cohort of untreated children with typical absence seizures (AS). Our aim was to identify cortical and subcortical regions involved in spike and wave events and to explore the timing of activity in these regions. Methods: Eleven children with AS confirmed on video-EEG underwent EEG-fMRI. An event-related analysis of epileptiform activity was performed. Regions of interest (ROIs), identified in the event-related analysis, were used to study the time course of the blood oxygen level-dependent (BOLD) signal prior to and immediately following events of interest in these ROIs. Results: Group analysis confirmed positive BOLD in the th..
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Funding Acknowledgements
Study funding: Supported by Pfizer Inc. (Neuroscience Research Grant), the National Health and Medical Research Council of Australia (NHMRC), and the Dowd Foundation (P. W. C.).Dr. Carney has received scholarship support from the Dowd Foundation. Dr. Masterton and Dr. Harvey report no disclosures. Prof. Scheffer has served on scientific advisory boards for and received funding for travel from UCB and Janssen-Cilag EMEA; serves on the editorial boards of the Annals of Neurology and Epilepsia; may accrue future revenue on pending patents re: Therapeutic Compound; has received speaker honoraria from UCB, Janssen-Cilag EMEA, and Eli Lilly and Company; and receives/has received research support from the NHMRC, Health Research Council of New Zealand, The University of Melbourne, the Jack Brockhoff Foundation, and the Perpetual Charitable Trustees. Prof. Berkovic has served on scientific advisory boards for UCB and Janssen-Cilag EMEA; has received funding for travel and honoraria from UCB; serves/has served on the editorial boards of Brain and Epileptic Disorders; and has received research support from UCB, the NHMRC, and the American Epilepsy Society. Prof. Jackson serves on a scientific advisory board for Neurosciences Victoria; receives royalties from the publication of Magnetic Resonance in Epilepsy, 2<SUP>nd</SUP> ed. (Elsevier, 2005); and receives/has received research support from the NHMRC.