Journal article
Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: Cohort study
SR Kadri P, I Lao-Sirieix, M O'Donovan, I Debiram, M Das, JM Blazeby, J Emery, A Boussioutas, H Morris, FM Walter, P Pharoah, RH Hardwick, RC Fitzgerald
BMJ Online | Published : 2010
DOI: 10.1136/bmj.c4372
Abstract
Objectives: To determine the accuracy and acceptability to patients of non-endoscopic screening for Barrett's oesophagus, using an ingestible oesophageal sampling device (Cytosponge) coupled with immunocytochemisty for trefoil factor 3. Design: Prospective cohort study. Setting: 12 UK general practices, with gastroscopies carried out in one hospital endoscopy unit. Participants: 504 of 2696 eligible patients (18.7%) aged 50 to 70 years with a previous prescription for an acid suppressant (H2 receptor antagonist or proton pump inhibitor) for more than three months in the past five years. Main outcome measures: Sensitivity and specificity estimates for detecting Barrett's oesophagus compared w..
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Awarded by Medical Research Council
Funding Acknowledgements
This research was supported by the Medical Research Council development gap fund, NIHR School for Primary Care Research, BD Diagnostics, Cambridge Experimental Cancer Medicine Centre, and the National Institute for Health Research Cambridge Biomedical Research Centre. Surepath preservative fluid was a gift from BD Diagnostics.