Pilot comparison of 18F-fluorocholine and 18F- fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer

Abstract

Introduction: Conventional imaging (CI) is known to have limitations with respect to staging of patients with primary or relapsed prostate cancer. Positron emission tomography/computed tomography (PET/CT) with 18F-flurodeoxyglucose (FDG) is also often suboptimal because of low tracer avidity, but 18F-fluorocholine (FCH) appears to be a promising alternative molecular imaging probe. We report a prospective pilot study of PET/CT comparing both tracers for staging and restaging of patients with prostate cancer. Methods: Sixteen prostate cancer patients were evaluated (7 for staging and 9 for restaging). All patients also underwent CI, comprising at least an abdominopelvic CT and a bone scan. Al..