Implantation of Functionalized Thermally Gelling Xyloglucan Hydrogel Within the Brain: Associated Neurite Infiltration and Inflammatory Response
David R Nisbet, Andrew E Rodda, Malcolm K Horne, John S Forsythe, David I Finkelstein
TISSUE ENGINEERING PART A | MARY ANN LIEBERT, INC | Published : 2010
To develop neural tissue engineering strategies that are useful for repairing damaged neural pathways in the central nervous system, it is essential to control and optimise neurone and neurite interactions with functional scaffolds. In this study, the suitability of thermally gelling xyloglucan hydrogels, along with xyloglucan-graft-poly-D-lysine (PDL) hydrogels, was assessed through their implantation within the caudate putamen of adult rats. The ability of the hydrogel scaffolds to encourage the infiltration of axons in a controlled manner was investigated, as was the inflammatory response associated with the implantation. The microglia reaction was the same for unmodified xyloglucan and t..View full abstract
Awarded by Australian Research Council
We are grateful to the Australian Research Council Postdoctoral Fellowship (to D.R.N.), and the Australian Research Council Discovery Project (DP0985433) (to J.S.F. and D.R.N.) and the Cooperative Research Centre for Polymers (to A. E. R.) for funding. We also acknowledge The CASS Foundation's small grant (to DRN, DIF and JSF) for support.