Assessing oxidative pathway genes as risk factors for bipolar disorder
Janice M Fullerton, Yash Tiwari, Giti Agahi, Anna Heath, Michael Berk, Philip B Mitchell, Peter R Schofield
BIPOLAR DISORDERS | WILEY | Published : 2010
OBJECTIVES: There is a growing body of evidence implicating oxidative stress and the glutathione system in the pathogenesis of major psychiatric illnesses, including schizophrenia and bipolar disorder. Here we investigate whether genes involved in oxidative stress regulation are associated with increased risk for bipolar disorder. METHODS: Four candidate genes were selected a priori from two different steps in the oxidative stress pathway, specifically the synthesis of glutathione [catalytic subunit of glutamate cysteine ligase (GCLC) and regulatory subunit of glutamate cysteine ligase (GCLM)] and the removal of reactive oxygen species [superoxide dismutase 2 (SOD2) and glutathione peroxidas..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
We express our thanks to Dr. Juleen A. Cavanaugh of the Medical Genetics Research Unit, Australian National University Medical School, for her kind donation of the DNA samples from the Australian volunteer blood donor control cohort. This study was supported by the Australian National Health and Medical Research Council (NHMRC) Howard Florey Fellowship (325643) to JMF, project grants to PRS (510216) and MB (454356 and 509103), program grants to PBM (510135) and MB (350241), and the Stanley Medical Research Institute to MB and JMF.