Journal article

Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study

Miranda L Davies-Tuck, Anita Wluka, Andrew Forbes, Yuanyuan Wang, Dallas R English, Graham G Giles, Richard O'Sullivan, Flavia M Cicuttini



INTRODUCTION: To examine the relationship between development or resolution of bone marrow lesions (BMLs) and knee cartilage properties in a 2 year prospective study of asymptomatic middle-aged adults. METHODS: 271 adults recruited from the Melbourne Collaborative Cohort Study, underwent a magnetic resonance imaging scan (MRI) of their dominant knee at baseline and again approximately 2 years later. Cartilage volume, cartilage defects and BMLs were determined at both time points. RESULTS: Among 234 subjects free of BMLs at baseline, 33 developed BMLs over 2 years. The incidence of BMLs was associated with progression of tibiofemoral cartilage defects (OR 2.63 (95% CI 0.93, 7.44), P = 0.07 fo..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We would especially like to thank the study participants who made this study possible. The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council of Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057) and was further supported by infrastructure provided by The Cancer Council of Victoria. We would like to acknowledge the NHMRC (project grant 334150) and Colonial Foundation. Drs Wluka and Wang are the recipients of NHMRC Public Health Fellowships (317840 and 465142, respectively). Ms Davies-Tuck is the recipient of Australian Post-graduate Award PhD Scholarship.