Journal article

Distinct Patterns of Gene-Specific Methylation in Mammalian Placentas: Implications for Placental Evolution and Function

HK Ng, B Novakovic, S Hiendleder, JM Craig, CT Roberts, R Saffery

PLACENTA | W B SAUNDERS CO LTD | Published : 2010


The placenta has arisen relatively recently and is among the most rapidly evolving tissues in mammals. Several different placental barrier and structure types appear to have independently evolved common functional features. Specific patterns of gene expression that determine placental development in humans are predicted to be accompanied by specific profiles of epigenetic modification. However, the stratification of epigenetic modifications into those involved in conserved aspects of placental function, versus those involved in divergent placental features, has yet to begin. As a first step towards this goal, we have investigated the methylation status of a small number of gene-specific meth..

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Funding Acknowledgements

We would like to thank Dr Neroli Sunderland (Royal Prince Alfred Hospital, Australia) for full term placental tissue and CVS samples, Drs Patrick Western and Craig Smith (Murdoch Childrens Research Institute, Australia) for mouse placental tissue, Monash Animal Services (Australia) for Marmoset placental tissue, and Dr Chris Thurgood (RSPCA, Victoria) for feline placental tissue. This work was funded by National Health and Medical Research Council (Australia) special grant to JC and RS. SH is a JS Davies Fellow.