Journal article

Novel Burkholderiales 23S rRNA Genes Identified in Ileal Biopsy Samples from Children: Preliminary Evidence that a Subtype Is Associated with Perianal Crohn's Disease

WH Sim, J Wagner, DJ Cameron, AG Catto-Smith, RF Bishop, CD Kirkwood

Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2010


A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.


Funding Acknowledgements

W. H. Sim is a recipient of a Melbourne International Research Scholarship from the University of Melbourne. C. D. Kirkwood is an NHMRC CDA Fellow (334 364). This research was supported by research grants from the CASS foundation, the Lynne Quayle Charitable Trust, and Murdoch Childrens Research Institute.