Journal article

Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases

Erick T Tatro, Erick R Scott, Timothy B Nguyen, Shahid Salaria, Sugato Banerjee, David J Moore, Eliezer Masliah, Cristian L Achim, Ian P Everall

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2010

Abstract

HIV infection disturbs the central nervous system (CNS) through inflammation and glial activation. Evidence suggests roles for microRNA (miRNA) in host defense and neuronal homeostasis, though little is known about miRNAs' role in HIV CNS infection. MiRNAs are non-coding RNAs that regulate gene translation through post-transcriptional mechanisms. Messenger-RNA profiling alone is insufficient to elucidate the dynamic dance of molecular expression of the genome. We sought to clarify RNA alterations in the frontal cortex (FC) of HIV-infected individuals and those concurrently infected and diagnosed with major depressive disorder (MDD). This report is the first published study of large-scale miR..

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University of Melbourne Researchers