Protein export in Plasmodium parasites: From the endoplasmic reticulum to the vacuolar export machine
Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
INTERNATIONAL JOURNAL FOR PARASITOLOGY | ELSEVIER SCI LTD | Published : 2010
It is somewhat paradoxical that the malaria parasite's survival strategy involves spending almost all of its blood-stage existence residing behind a two-membrane barrier in a host red blood cell, yet giving considerable attention to exporting parasite-encoded proteins back across these membranes. These exported proteins are thought to play diverse roles and are crucial in pathogenic processes, such as re-modelling of the erythrocyte cytoskeleton and mediating the export of a major virulence protein known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), and in metabolic processes such as nutrient uptake and solute exchange. Despite these varied roles most exported proteins ha..View full abstract
We thank Paul Sanders for critical reading of this manuscript. This work was supported by the National Health and Medical Research Council of Australia.