Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study

Katrina L Hannan; Stephen J Wood; Alison R Yung; Dennis Velakoulis; Lisa J Phillips; Bridget Soulsby; Gregor Berger; Patrick D McGorry; Christos Pantelis

Journal article

Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study

Katrina L Hannan, Stephen J Wood, Alison R Yung, Dennis Velakoulis, Lisa J Phillips, Bridget Soulsby, Gregor Berger, Patrick D McGorry, Christos Pantelis

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2010

DOI: 10.1016/j.pscychresns.2010.02.006

Abstract

The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psychotic illness. Caudate nuclei volume (CNVs), excluding the tail, were measured using region-of-interest (ROI) tracing of magnetic resonance imaging (MRI) scans acquired on a 1.5T scanner. Subjects included 39 individuals deemed at ultra-high risk of psychosis who converted to psychosis (UHR-P) after initial MRI scanning; 39 matched individuals at ultra-high risk who did not convert to psychosis (UHR-NP); and 39 matched healthy controls. All subjects were neuroleptic-naïve. After adjusting CNVs for intracranial volume (ICV), univariate analyses of variance and repeat..

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University of Melbourne Researchers

Christos Pantelis Author Psychiatry

Stephen Wood Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

Lisa Phillips Author Melbourne School of Psychological Sciences

Dennis Velakoulis Author Psychiatry

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms. Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The research was supported by the Melbourne Neuropsychiatry Centre (Sunshine Hospital), Department of Psychiatry, the University of Melbourne, the National Health and Medical Research Council (ID 236175; 350241) and NHMRC Program Grants (IDs: 350241, 566529). Christos Pantelis was supported by NHMRC Senior Principal Research Fellowship (ID: 628386). Stephen J Wood was supported by an NHMRC Clinical Career Development Award (ID: 359223) and a NARSAD Young Investigator Award. We thank Anthony Ang (AA) for undertaking reliability measures. The authors report no biomedical financial interests or potential conflicts of interest related to this study.