A comparison of statistical approaches used to evaluate change in cognitive function following pharmacologic challenge: an example with lorazepam
Robert H Pietrzak, Amy Fredrickson, Peter J Snyder, Paul Maruff
Human Psychopharmacology - Clinical and Experimental | WILEY-BLACKWELL | Published : 2010
BACKGROUND: Neuropsychological tests are commonly used in psychopharmacological research to understand the nature and the magnitude of cognitive effects of licensed and novel compounds. While the science of cognitive change assessment has advanced considerably, statistical techniques used to guide inferences about differences in cognitive change have not been considered in the same detail, especially in light of recent advances in modeling repeated data. METHODS: Data from a randomized, placebo-controlled, crossover study of the effect of an acute dose of lorazepam on cognitive function in healthy adults were analyzed using five statistical approaches (paired sample t-test, area under curve ..View full abstract
Dr Pietrzak receives partial salary support from CogState, Ltd., a cognitive test company that provides the cognitive tests used in this study. Dr Maruff and Ms Fredrickson are full-time employees of CogState, Ltd., and Dr Snyder is a consultant to this company.