Three-Dimensional Nanofibrous Scaffolds Incorporating Immobilized BDNF Promote Proliferation and Differentiation of Cortical Neural Stem Cells
Malcolm K Horne, David R Nisbet, John S Forsythe, Clare L Parish
Stem Cells and Development | MARY ANN LIEBERT, INC | Published : 2010
Attempts to repair the central nervous system damaged as a result of trauma or disease will depend on the ability to restore the appropriate neuronal connectivity. This will rely on establishing appropriate chemical and physical environments for supporting neural cells and their processes and in this regard, engineering of biomaterials is of increasing interest. It will be important to understand how cells behave on these biomaterials in vitro, prior to future in vivo application. We reveal that modification of 3-dimensional (3D) electrospun poly-epsilon-caprolactone (PCL) nanofiber scaffolds by fiber alignment and aminolysation is superior to classical 2-dimensional (2D) culture-ware in pro..View full abstract
Awarded by Australian Research Council
This work was supported by grants from the Australian Research Council (DP0985433) and National Health and Medical Research Australia (NHMRC). C.L.P is supported by a National Health and Medical Research Australia (NHMRC) C.J. Martin Fellowship and NHMRC Career Development Award. D.R.N is supported by an ARC Postdoctorate Fellowship.