Journal article
A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes
JE Pryce, S Bolormaa, AJ Chamberlain, PJ Bowman, K Savin, ME Goddard, BJ Hayes
Journal of Dairy Science | Published : 2010
Abstract
Genome-wide association studies (GWAS) were used to discover genomic regions explaining variation in dairy production and fertility traits. Associations were detected with either single nucleotide polymorphism (SNP) markers or haplotypes of SNP alleles. An across-breed validation strategy was used to narrow the genomic interval containing causative mutations. There were 39,048 SNP tested in a discovery population of 780 Holstein sires and validated in 386 Holsteins and 364 Jersey sires. Previously identified mutations affecting milk production traits were confirmed. In addition, several novel regions were identified, including a putative quantitative trait loci for fertility on chromosome 18..
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Funding Acknowledgements
The authors thank Australian Dairy Herd Improvement Scheme (Melbourne, Australia) for providing the phenotype data used in this study. We also thank the funders of this research, the Department of Primary Industries Our Rural Landscapes Initiative. Finally, we are grateful to Curt van Tassell and Tad Sonstegard from the USDA (Beltsville, MD) for providing genotypes of Australian bulls under a collaborative agreement between USDA and Department of Primary Industries Victoria (Melbourne, Australia).