Journal article

Intravitreal Methotrexate as Adjunctive, Palliative Therapy in Intraocular T-cell Lymphoma

Sanjeewa S Wickremasinghe, Elvis Ojaimi, Lyndell Lim, Richard Stawell, Penelope McKelvie, Ehud Zamir

OCULAR IMMUNOLOGY AND INFLAMMATION | TAYLOR & FRANCIS INC | Published : 2010

Abstract

PURPOSE: To report on the rapid and sustained effect following injection of intravitreal methotrexate (IVTMTX) in intraocular T-cell lymphoma. DESIGN: Report of 2 cases. METHODS: A young male with natural killer/T-cell lymphoma presented with infiltrative nodular iridocyclitis and received a single IVTMTX. An elderly female with peripheral T-cell lymphoma presented with a hypopyon, infiltrative iridocyclitis, and choroidal effusions and received 3 IVTMTX over 4 months. RESULTS: Both patients responded well after the first injection, with resolution of signs within 1 week and improvement in vision. CONCLUSIONS: IVTMTX may be effective as a palliative, vision-restoring measure in patients with..

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