Journal article

Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness

Yi Lu, David P Dimasi, Pirro G Hysi, Alex W Hewitt, Kathryn P Burdon, Tze'Yo Toh, Jonathan B Ruddle, Yi Ju Li, Paul Mitchell, Paul R Healey, Grant W Montgomery, Narelle Hansell, Timothy D Spector, Nicholas G Martin, Terri L Young, Christopher J Hammond, Stuart Macgregor, Jamie E Craig, David A Mackey

PLoS Genetics | PUBLIC LIBRARY SCIENCE | Published : 2010


Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by National Eye Institute (NEI)

Awarded by NIH/NEI

Awarded by Netherlands Scientific Organization (NWO)

Awarded by EU

Awarded by Biotechnology and Biological Sciences Research Council (BBSRC)

Funding Acknowledgements

The Australian Twin Registry is supported by an Australian National Health and Medical Research Council (NHMRC) Enabling Grant (2004-2009). The Blue Mountains Eye Study has also been supported by NHMRC grants (974159, 211069, 457349), a Capacity Building grant (262120), and a Centre for Clinical Research Excellence grant (529923). We also thank the following organisations for their financial support: Clifford Craig Medical Research Trust, Ophthalmic Research Institute of Australia (ORIA), Glaucoma Australia, American Health Assistance Foundation (AHAF), Peggy and Leslie Cranbourne Foundation, Foundation for Children, NHMRC project grant (2005-2007), Jack Brockhoff Foundation, National Eye Institute (NEI) Project Grant (2007-2010). Genotyping for part of the Australian sample was funded by an NHMRC Medical Genomics Grant. Genotyping for the remainder was performed by the National Institutes of Health (NIH) and CIDR as part of an NIH/NEI grant 1RO1EY018246, and we are grateful to Dr Camilla Day and staff. Australian sample imputation analyses were carried out on the Genetic Cluster Computer which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003). YL is supported by Australian NHMRC grant 496675. DAM is a recipient of the Pfizer Australia Senior Research Fellowship. SM is supported by an Australian NHMRC Career Development Award. The KCL authors acknowledge funding from the Wellcome Trust, the EU MyEuropia Marie Curie Research Training Network, Guide Dogs for the Blind Association the European Community's Seventh Framework Programme (FP7/2007-2013)/grant agreement HEALTH-F2-2008-201865-GEFOS and (FP7/2007-2013), ENGAGE project grant agreement HEALTH-F4-2007-201413 and the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254). The study also receives support from the Dept of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London. TDS is an NIHR senior Investigator and CJH an NIHR Senior Research Fellow. The project also received support from a Biotechnology and Biological Sciences Research Council (BBSRC) project grant. (G20234). The authors acknowledge the funding and support of the NIH/NEI grant 1RO1EY018246, an NIH/Center for Inherited Diseases Research genotyping project grant (PI: Terri Young). Genotyping of the BMES and Adelaide cohorts was funded by the Ophthalmic Research Institute of Australia and NHMRC Project Grant # 535044. DPD is supported by NHMRC Dora Lush Scholarship and KPB by NHRMC Peter Foherty Fellowship. JEC is an NHMRC Practioner Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.