A naturally occurring variant of Hsp90 that is associated with decanalization
Carla M Sgro, Benjamin Wegener, Ary A Hoffmann
Royal Society of London. Proceedings B. Biological Sciences | ROYAL SOC | Published : 2010
The heat shock protein Hsp90 has been the focus of many studies since it was suggested that it acts to mediate the buffering of phenotypic variation. Hsp90-mediated buffering may result in the accumulation of cryptic genetic variation that, when released either as a consequence of environmental or genetic stress, increases the evolvability of a population. Recent studies using laboratory-induced mutations of Hsp90 and/or chemical inhibition to disrupt Hsp90 function confirm that Hsp90 can buffer cryptic genetic variation. We have previously identified a naturally occurring variant in the charged linker region of the Hsp90 gene, and now examine whether this variant is associated with altered ..View full abstract
We thank Jodie Taylor, Alen Rako, Christina Schmuki and Vanessa Kellermann for technical assistance and the Australian Research Council for financial support via their Fellowship (to both CMS, AAH) and Discovery grant schemes.