fMRI assessment of language lateralization: An objective approach
David F Abbott, Anthony B Waites, Leasha M Lillywhite, Graeme D Jackson
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010
Language lateralization based on functional magnetic resonance imaging (fMRI) is often used in clinical neurological settings. Currently, interpretation of the distribution, pattern and extent of language activation can be heavily dependent on the chosen statistical threshold. The aim of the present study was to 1) test the robustness of adaptive thresholding of fMRI data to yield a fixed number of active voxels, and to 2) develop a largely threshold-independent method of assessing when individual patients have statistically atypical language lateralization. Simulated data and real fMRI data in 34 healthy controls and 4 selected epilepsy patients performing a verbal fluency language fMRI tas..View full abstract
Related Projects (1)
Awarded by National Health and Medical Research Council of Australia
The authors would like to thank Marnie E. Shaw for helpful discussions during preparation of the manuscript, and acknowledge funding from the National Health and Medical Research Council of Australia (primarily NHMRC project grant 368650; some data used were acquired as part of program grant 400121 and project grants 318900 and 226100).