Journal article

fMRI assessment of language lateralization: An objective approach

David F Abbott, Anthony B Waites, Leasha M Lillywhite, Graeme D Jackson

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010

Abstract

Language lateralization based on functional magnetic resonance imaging (fMRI) is often used in clinical neurological settings. Currently, interpretation of the distribution, pattern and extent of language activation can be heavily dependent on the chosen statistical threshold. The aim of the present study was to 1) test the robustness of adaptive thresholding of fMRI data to yield a fixed number of active voxels, and to 2) develop a largely threshold-independent method of assessing when individual patients have statistically atypical language lateralization. Simulated data and real fMRI data in 34 healthy controls and 4 selected epilepsy patients performing a verbal fluency language fMRI tas..

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