Journal article
The effects of vasopressin on acute kidney injury in septic shock
AC Gordon, JA Russell, KR Walley, J Singer, D Ayers, MM Storms, CL Holmes, PC Hébert, DJ Cooper, S Mehta, JT Granton, DJ Cook, JJ Presneill
Intensive Care Medicine | SPRINGER | Published : 2010
Abstract
Objective: To compare the effects of vasopressin versus norepinephrine infusion on the outcome of kidney injury in septic shock. Design and setting: Post-hoc analysis of the multi-center double-blind randomized controlled trial of vasopressin versus norepinephrine in adult patients who had septic shock (VASST). Patients and intervention: Seven hundred seventy-eight patients were randomized to receive a blinded infusion of either low-dose vasopressin (0.01-0.03 U/min) or norepinephrine infusion (5-15 μg/min) in addition to open-label vasopressors and were included in the outcome analysis. All vasopressors were titrated and weaned to maintain a target blood pressure. Measurement and results: R..
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Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
Support: Canadian Institutes of Health Research, grant number: MCT 44152. Registration: IS-RCTN94845869, http://www.controlled-trials.com. Anthony C. Gordon is grateful for support from the NIHR Biomedical Research Centre funding scheme. Keith R. Walley is a Michael Smith Foundation for Health Research Distinguished Scholar. Deborah J. Cook is a Chair of the Canadian Institutes of Health Research.