Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells
Daniela Babovic, Luning Jiang, Ilse Gantois, Andrew J Lawrence, Vincenzo Ferreri, Guenter Schuetz, John L Waddington, John Drago
Behavioural Brain Research | ELSEVIER SCIENCE BV | Published : 2010
In this study we characterize the behavioural and cellular phenotype of mutant (MUT) mice with progressive loss of D1 dopamine receptor (Drd1a)-expressing cells. Adult [14-19 weeks] MUT mice showed intact working memory in the spontaneous alternation test but evidenced anxiety-like behaviour in the elevated plus maze and the light-dark test. The ethogram of mature adult MUT [average age 22 weeks] was compared with that of young adult MUT mice [average age 12 weeks]. While MUT mice evidenced hyperactivity over initial exploration at both time points, the topography of hyperactivity shifted. Moreover, initial hyperactivity was sustained over habituation at 12 weeks, but not at 22 weeks. Thus, ..View full abstract
These studies were supported by a project grant from the Australian National Health and Medical Research Council (NHMRC), Science Foundation Ireland and the Health Research Board of Ireland. We thank Jim Massalas for technical assistance with geno-typing mice used in this study. John Drago is a NHMRC Practitioner Fellow.